The 2021 Midlands Region 4 Senior Honors Orchestra is comprised of students in the 11th and 12th grades and is conducted by Scott Laird. Their selections are:
- Blindsided – Peter Terry
- Eine Kleine Nacht Musik, I. Allego, II. Andante-Romanze – W.A. Mozart
- Danzas de Panama, II. Mejorana y Socavon, IV. Cumbia y Congo – William Grant Still
- Tango Toscano – Jeremy Cohen